The sympathomimetic action of local anaesthetics

The protective action of anaesthetics against hypoxia.

UNTIL RECENTLY interest in examining the protective action of anaesthetics on brain cells exposed to hypoxia has been sporadic (for references see WilhjelmX). In recent years different groups of investigators in Canada, 2 USA, a,4 India, ~ and Denmark 1,6-s have shown interest in this problem. For many years it has been recognized that barbiturates were able to reduce the cerebral oxygen uptake...

The action of sympathomimetic amines in animals treated with reserpine.

A comparison of local anaesthetics for venepuncture.

AIM To compare the effectiveness of EMLA cream and Ametop gel in providing analgesia for venous cannulation. METHODS Single blind study in 120 children. RESULTS Both anaesthetic agents produced adequate analgesia. However, Ametop gel was more effective, with a statistically significant difference in the pain scores of the two groups (p < 0.05).

Quinidine like activity of eight local anaesthetics.

and Md., Eight synthetic local anaesthetics from among (he Propiophenones, Benzil and Phenoxy derivatives and derivatives of Benzyl alcohol wen' examined for their arrhvthmia combating activity. Against acetylcholine induced auricular fibrillation U·0045 showed maximum activity and U -0172, U·OI77, U-OS75 and Lignocaine were more active than quinidine. In aconitine induced fibrillation li.OI77,...

INVESTIGATIONS ON THE DRUG-PROTEIN IN TERAC TION OF CERTAIN NEW POTENTIAL LOCAL ANAESTHETICS

Generally, plasma proteins owe their binding capacity to the presence of aminoacid units which enter into intra- and intermolecular hydrophobic bonding with a diverse range of endo- and exogenous chemical substances. The intermolecular interactions between the hydrophobic areas of drug molecules and those of plasma proteins play an important role in drug-macromolecular complex formation and...